Objectives：

• To improve quantitative accuracy of clinical protocols conducted using commercially available SPECT cameras.
• To establish imaging and data-processing protocols to support inter-institutional consistency in clinical examinations using existing SPECT systems.
• To support quantitative assessment of various functional-parametric images, such as regional cerebral blood flow, vascular reactivity, myocardial perfusion, myocardial flow reserve, binding potentials for various neuro receptor ligands.
• To support multi-center clinical trials which employ SPECT equipments.

Activities：

• Development of a software package of quantitative SPECT reconstruction
• Standardization of a protocol of quantitative assessment of CBF and CVR using SPECT cameras for clinical diagnosis of ischemic cerebral disease
• Quantitation of neuro receptor binding potentials using SPECT
• Confirmation of inter-institutional consistency, in regard to the normal CBF and CVR values and reproducibility
• Promotion of the need for quality control in clinical SPECT
• Validation of quantitative assessment of regional myocardial perfusion and coronary flow reserve with CT/SPECT
• Development of various physical phantoms for evaluating SPECT accuracy